Description
The abstract reports sex-dependent reciprocal induction of AD risk factors with MGnD gene suppression in females carrying APOE4, but provides no mechanistic explanation. Understanding this sex dimorphism is critical for developing personalized AD therapeutics.
Gap type: unexplained_observation Source paper: APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints. (None, None, PMID:37749326)