What are the direct molecular targets of ginsenoside Rk1 that initiate its neuroprotective cascade?

While molecular docking suggests binding affinities with PI3K/Akt proteins, the primary molecular target(s) and initial binding events that trigger the observed anti-inflammatory and synaptic effects are not identified. This limits understanding of the compound’s mechanism of action.

Gap type: unexplained_observation Source paper: Ginsenoside Rk1 alleviates lipopolysaccharide (LPS)-induced cognitive impairment by modulating synaptic plasticity. (2025, Frontiers in pharmacology, PMID:41646936)