Description
The study reveals that healthy macrophages upregulate peroxisomal genes during myelin phagocytosis, but this response is impaired in MS patients. The mechanistic basis for this disease-specific dysfunction remains unexplained, yet could reveal key pathogenic pathways in MS neuroinflammation.
Gap type: unexplained_observation Source paper: Efficacy of HDAC Inhibitors in Driving Peroxisomal β-Oxidation and Immune Responses in Human Macrophages: Implications for Neuroinflammatory Disorders. (2023, Biomolecules, PMID:38136568)