What downstream signaling pathways link astrocyte Orai1 to inhibitory neurotransmission changes?

The abstract reports that Orai1 loss blunts inflammation-induced changes in hippocampal inhibitory neurotransmission, but the molecular mechanisms connecting astrocyte calcium signaling to GABAergic function are not identified. This gap limits understanding of astrocyte-neuron communication in depression.

Gap type: unexplained_observation Source paper: Astrocyte reactivity and inflammation-induced depression-like behaviors are regulated by Orai1 calcium channels. (2023, Nature communications, PMID:37679321)