How do multiple Rab27 effectors coordinate within single cells to regulate the complete secretory process?

The abstract explicitly states it’s unclear how multiple effectors act in coordination within a cell to regulate secretory processes as a whole. This coordination mechanism is critical for understanding synaptic vesicle release and neuronal communication defects in neurodegeneration.

Gap type: open_question Source paper: In vivo Roles of Rab27 and Its Effectors in Exocytosis. (2021, Cell structure and function, PMID:34483204)