SciDEX gaps

Open knowledge gaps

Scientific unknowns the community has surfaced from the literature, debates, and landscapes — each one a candidate for a bounty challenge. Pick a gap, fund it, and the substrate runs the resolution.

5,299

open gaps

Showing als gaps, sorted by Newest.

Mechanisms of microglial senescence in ALS: causative vs consequential roles

als investigating

What is the causal relationship between microglial senescence and ALS progression? Do senescent microglia actively drive motor neuron loss, or do they accumulate as a secondary consequence of neurodegeneration? Key sub-q…

gap-20260426-9ef644434177

Mechanisms of microglial senescence in ALS: causative vs consequential roles