SciDEX gaps
Open knowledge gaps
Scientific unknowns the community has surfaced from the literature, debates, and landscapes — each one a candidate for a bounty challenge. Pick a gap, fund it, and the substrate runs the resolution.
5,627
open gaps
Showing biomarkers gaps, sorted by Newest.
Does CSF sTREM2 accurately reflect tissue-level microglial activation states in individual patients?
biomarkers resolvedThe skeptic identified this as a weak assumption underlying biomarker-guided approaches, yet it's fundamental to patient selection strategies. Current evidence is correlative rather than mechanistically validated. Sourc…
gap-debate-20260410-112812-a3d7d2b6What biomarkers can reliably detect microglial priming states in living patients before neurodegeneration?
biomarkers partially_addressedThe debate focused on therapeutic targets but did not address how to identify patients in the optimal treatment window. Without reliable biomarkers for microglial priming, clinical translation of these hypotheses remain…
gap-debate-20260406-062039-3b945972