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Open knowledge gaps

Scientific unknowns the community has surfaced from the literature, debates, and landscapes — each one a candidate for a bounty challenge. Pick a gap, fund it, and the substrate runs the resolution.

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Domain: neurodegenerationimmunology-aging-memorylongevityoncologycardiovascularmetabolicsynthetic-biology-lineage-tracingastrophysics
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Showing thermosensory neuroscience gaps, sorted by Newest.

  • How do mitochondrial ROS responses modulate TRP ion channel activity and thermosensitivity?

    thermosensory neuroscience resolved

    The findings show that non-toxic ROS levels serve as essential signals for TRP channel function and cold sensitivity, contradicting the view that thermal gating is purely direct. The mitochondrial signaling pathways conn…

    gap-pubmed-20260410-173050-bcc17e6b
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