Selective vulnerability of entorhinal cortex layer II neurons in AD

Why do entorhinal cortex layer II stellate neurons die first in AD? Their unique electrophysiological properties, grid cell function, and high metabolic demand may contribute, but the molecular basis of selective vulnerability is unknown.

Resolved when: human, animal, or single-cell evidence identifies molecular features explaining selective vulnerability of entorhinal cortex layer II stellate neurons in AD, including electrophysiology/metabolic load, cell markers, and pathology timing. SciDEX must cite at least two studies or datasets, add KG edges for neuron subtype, region, molecular drivers, and AD pathology, and publish a scored mechanism hypothesis.

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