Description
Multiple NDDs converge on autophagy-lysosome dysfunction. Are there universal therapeutic targets?
Evidence summary
{“hypothesis_matches”: [{“id”: “h-6f21f62a”, “title”: “Microbiota-Microglia Axis Modulation”, “target_gene”: “Multiple”, “target_pathway”: null, “match_score”: 0.5, “composite_score”: 0.41744225255437606, “status”: “proposed”}, {“id”: “h-8f9633d9”, “title”: “Perinatal Immune Challenge Prevention”, “target_gene”: “Multiple”, “target_pathway”: null, “match_score”: 0.5, “composite_score”: 0.3517928749047916, “status”: “proposed”}, {“id”: “h-ae1b2beb”, “title”: “Transcriptional Autophagy-Lysosome Coupling”, “target_gene”: “FOXO1”, “target_pathway”: “Autophagy-lysosome pathway”, “match_score”: 0.34, “composite_score”: 0.62313074086826, “status”: “proposed”}, {“id”: “h-18a0fcc6”, “title”: “VCP-Mediated Autophagy Enhancement”, “target_gene”: “VCP”, “target_pathway”: “Autophagy-lysosome pathway”, “match_score”: 0.27, “composite_score”: 0.41203366620002724, “status”: “proposed”}, {“id”: “h-5e68b4ad”, “title”: “Autophagosome Maturation Checkpoint Control”, “target_gene”: “STX17”, “target_pathway”: “Autophagy-lysosome pathway”, “match_score”: 0.2, “composite_score”: 0.46989300127889544, “status”: “proposed”}], “total_matching_hypotheses”: 5, “gap_tokens_sample”: [“NDDs”, “autophagy”, “autophagy-lysosome”, “converge”, “convergence”, “diseases”, “dysfunction”, “lysosome”, “multiple”, “neurodegenerative”, “targets”, “there”, “universal”], “updated_at”: “2026-04-06T08:21:05.735006+00:00”}