Senolytic therapy for age-related neurodegeneration

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Composite

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Priority

86%

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Tractability

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Market price

50%

Description

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP-driven neuroinflammation.

Evidence summary

{“hypothesis_matches”: [{“id”: “h-3f02f222”, “title”: “Senescent Microglia Resolution via Maresins-Senolytics Combination”, “target_gene”: “BCL2L1”, “target_pathway”: “Microglial activation / TREM2 signaling”, “match_score”: 0.2, “composite_score”: 0.5304766007638354, “status”: “proposed”}], “total_matching_hypotheses”: 1, “gap_tokens_sample”: [“SASP”, “SASP-driven”, “astrocytes”, “microglia”, “neurodegeneration”, “neuroinflammation”, “reduce”, “sasp-driven”, “senescent”, “senolytic”, “senolytics”, “targeting”], “updated_at”: “2026-04-06T08:21:05.741541+00:00”}

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