Blood-brain barrier permeability changes as early biomarkers for neurodegeneration

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Description

What is the evidence that blood-brain barrier (BBB) permeability changes serve as early biomarkers for neurodegeneration?

Focus areas:

CSF biomarker panels for BBB dysfunction (tight junction proteins like claudin-5, zonula occludens-1; pericyte markers like PDGFR-beta)
Blood-based BBB permeability indicators (S100B, NFL, GFAP in plasma vs CSF)
Dynamic contrast-enhanced MRI measures of BBB leakage as early AD/PD markers
Relationship between BBB disruption and neurovascular uncoupling preceding motor/cognitive symptoms
Comparative utility of BBB permeability markers vs amyloid/tau PET for early detection

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