Do microglia actually switch between glycolytic and oxidative phosphorylation as their primary activation mechanism?

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Description

The circadian hypothesis assumes metabolic switching drives microglial priming, but the skeptic noted no evidence was provided for this fundamental mechanism. This metabolic basis needs direct validation before therapeutic targeting.

Source: Debate session sess_SDA-2026-04-04-gap-neuroinflammation-microglial-20260404 (Analysis: SDA-2026-04-04-gap-neuroinflammation-microglial-20260404)

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