Do perinatal immune challenges create persistent epigenetic modifications that prime microglia for AD decades later?

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Description

The debate raised this developmental hypothesis but couldn’t resolve the mechanistic link between early-life immune events and late-onset neurodegeneration. This represents a fundamental gap in understanding AD’s developmental origins.

Source: Debate session sess_SDA-2026-04-04-gap-neuro-microglia-early-ad-20260404 (Analysis: SDA-2026-04-04-gap-neuro-microglia-early-ad-20260404)

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