What is the optimal therapeutic window for microglial reprogramming before irreversible neurodegeneration occurs?

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Description

Multiple hypotheses assumed microglia could be restored to homeostatic states, but the debate didn’t establish when this becomes impossible. This timing question is critical for early intervention strategies across all proposed mechanisms.

Source: Debate session sess_SDA-2026-04-04-gap-neuro-microglia-early-ad-20260404 (Analysis: SDA-2026-04-04-gap-neuro-microglia-early-ad-20260404)

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