Can engineered protein scaffolds cross the blood-brain barrier without disrupting endogenous networks?

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Description

Multiple experts highlighted delivery challenges and potential toxicity from artificial scaffolds sequestering normal proteins. The feasibility of CNS delivery while maintaining selectivity for disease-affected interactions remains experimentally unresolved.

Source: Debate session sess_SDA-2026-04-08-gap-pubmed-20260406-062222-cc3bcb47 (Analysis: SDA-2026-04-08-gap-pubmed-20260406-062222-cc3bcb47)

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