Can mitochondrial-cytosolic proteostasis coupling be enhanced without disrupting normal mitochondrial function?

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Description

UPRmt activation was proposed but the debate didn’t resolve whether therapeutic enhancement of this pathway would interfere with essential mitochondrial processes. The therapeutic index remains undefined.

Source: Debate session sess_SDA-2026-04-08-gap-pubmed-20260406-062207-b800e5d3 (Analysis: SDA-2026-04-08-gap-pubmed-20260406-062207-b800e5d3)

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