How do astrocytes transfer chromatin-modifying metabolites to neurons and how is this disrupted in aging?

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Description

The glial-neuronal cross-talk hypothesis was ranked highest for therapeutic potential, but the specific molecular mechanisms of metabolite transfer between cell types remain unclear. Understanding this pathway is essential for designing dual-cell-type therapeutic approaches.

Source: Debate session sess_SDA-2026-04-04-gap-epigenetic-reprog-b685190e (Analysis: SDA-2026-04-04-gap-epigenetic-reprog-b685190e)

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