Can pulsed vs continuous OSK expression achieve partial reprogramming without neuronal dedifferentiation?

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Description

The debate highlighted that cited studies used continuous OSK expression, but the hypothesis requires precise temporal control. The critical question of whether neurons can undergo partial reprogramming while maintaining identity remains unresolved and is essential for therapeutic viability.

Source: Debate session sess_SDA-2026-04-04-gap-epigenetic-reprog-b685190e (Analysis: SDA-2026-04-04-gap-epigenetic-reprog-b685190e)

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