How do AD pathological proteins specifically disrupt stellate neuron ion channel function?

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80%

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50%

Description

While ion channel dysfunction was proposed as a mechanism, the debate did not resolve how tau aggregates or amyloid specifically alter HCN1/Kv7 channels in stellate neurons versus other cell types. This mechanistic gap limits therapeutic development.

Source: Debate session sess_sda-2026-04-01-gap-004 (Analysis: sda-2026-04-01-gap-004)

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