What specific cellular machinery differences between brain regions select for distinct tau conformations?

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50%

Description

The debate highlighted that PSP and CBD show different pathology even in overlapping regions, but the molecular basis for cell-type specific tau processing remains unknown. Understanding these mechanisms could reveal druggable targets.

Source: Debate session sess_sda-2026-04-01-gap-005 (Analysis: sda-2026-04-01-gap-005)

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