What is the therapeutic window between effective TDP-43 modulation and disruption of essential RNA processing functions?

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Description

All participants acknowledged that TDP-43 has critical normal functions in RNA metabolism, but no safety margins were established for therapeutic intervention. This represents a fundamental translational challenge for any TDP-43-targeting therapy.

Source: Debate session sess_sda-2026-04-01-gap-006 (Analysis: sda-2026-04-01-gap-006)

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