What are the minimal structural features required for PROTAC-mediated tau degradation without affecting essential HSP70 substrates?

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Description

The co-chaperone hijacking strategy was proposed but the specific molecular requirements for tau selectivity remain undefined. Understanding these requirements is critical for designing therapeutically viable compounds.

Source: Debate session sess_SDA-2026-04-10-SDA-2026-04-09-gap-debate-20260409-201742-5407d57d (Analysis: SDA-2026-04-09-gap-debate-20260409-201742-5407d57d)

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