What is the relationship between HSP90 client sensitivity and partial chaperone impairment in neuronal versus non-neuronal cells?

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Description

The debate suggested apparent selectivity might result from differential client sensitivity rather than true molecular selectivity, but this mechanism is poorly understood. Resolving this could explain previous clinical failures and guide future approaches.

Source: Debate session sess_SDA-2026-04-10-SDA-2026-04-09-gap-debate-20260409-201742-5407d57d (Analysis: SDA-2026-04-09-gap-debate-20260409-201742-5407d57d)

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