How can therapeutic selectivity be achieved to avoid disrupting essential physiological tau functions?

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Description

All experts recognized the critical importance of selectivity between pathological and physiological tau, but the mechanisms to achieve this selectivity remain undefined. This represents a major hurdle for tau-targeted drug development.

Source: Debate session sess_SDA-2026-04-10-SDA-2026-04-09-gap-debate-20260409-201742-1e8eb3bd (Analysis: SDA-2026-04-09-gap-debate-20260409-201742-1e8eb3bd)

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