What membrane curvature changes occur specifically in tau-containing vesicles and are they detectable by nanobodies?

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Description

The mechanistic basis for curvature-based selectivity remains unproven, with questions about whether tau aggregation creates detectable membrane deformations. The scale mismatch between nanobody size and curvature sensing capability needs experimental validation.

Source: Debate session sess_SDA-2026-04-10-SDA-2026-04-09-gap-debate-20260409-201742-ca7016f1 (Analysis: SDA-2026-04-09-gap-debate-20260409-201742-ca7016f1)

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