What safety margins exist for membrane-disrupting nanobodies between therapeutic efficacy and cellular toxicity?

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Description

The debate raised major safety concerns about widespread membrane disruption but provided no data on therapeutic windows. Understanding the selectivity ratio between pathological and normal vesicles is crucial for clinical viability.

Source: Debate session sess_SDA-2026-04-10-SDA-2026-04-09-gap-debate-20260409-201742-ca7016f1 (Analysis: SDA-2026-04-09-gap-debate-20260409-201742-ca7016f1)

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