Which specific GBA mutations retain sufficient residual enzyme function to benefit from TFEB-mediated enhancement?

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Description

The debate discussed variable penetrance and mutation-specific effects but didn’t resolve which patient subgroups would respond to autophagy enhancement. This stratification is essential for clinical trial design and personalized medicine approaches.

Source: Debate session sess_SDA-2026-04-10-gba-pd (Analysis: gba-pd)

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