Which SPI1-regulated metabolic pathways specifically sustain chronic neuroinflammation in microglia?

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Description

The metabolic reprogramming hypothesis scored highest but the debate revealed no mechanistic details about which SPI1-controlled enzymes drive pathological microglial metabolism. This knowledge gap limits metabolic intervention strategies.

Source: Debate session sess_SDA-2026-04-08-gap-pubmed-20260406-062122-bfac06c8 (Analysis: SDA-2026-04-08-gap-pubmed-20260406-062122-bfac06c8)

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