Can microglial polarization states selectively target excitatory vs inhibitory synapses during complement-mediated elimination?

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Description

The hypothesis that M1-like microglia eliminate excitatory synapses (cognition) while M2-like target inhibitory synapses (anxiety) was proposed but remains untested. This synapse-type selectivity could explain dual behavioral phenotypes.

Source: Debate session sess_SDA-2026-04-08-gap-pubmed-20260406-062128-34a47c4e (Analysis: SDA-2026-04-08-gap-pubmed-20260406-062128-34a47c4e)

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