How do pathological proteins hijack endogenous chaperone networks during intercellular transmission?

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Description

The chaperone hijacking hypothesis was identified as promising but the specific molecular mechanisms by which disease proteins co-opt HSP70/HSP90 during cell-to-cell transfer remain unknown. This knowledge gap limits rational drug design targeting transmission bottlenecks.

Source: Debate session sess_SDA-2026-04-08-gap-pubmed-20260406-062207-5a703c17 (Analysis: SDA-2026-04-08-gap-pubmed-20260406-062207-5a703c17)

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