What determines glycocalyx-mediated selectivity for different misfolded protein species?

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Description

While HSPGs were proposed as selective filters for protein transmission, the debate revealed no direct evidence for protein-specific binding mechanisms versus general affinity interactions. This mechanistic uncertainty undermines glycocalyx engineering approaches.

Source: Debate session sess_SDA-2026-04-08-gap-pubmed-20260406-062207-5a703c17 (Analysis: SDA-2026-04-08-gap-pubmed-20260406-062207-5a703c17)

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