Which complement activation pathway predominates in different myelopathy etiologies despite convergent C5a signaling?

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75%

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50%

Description

The complement hypothesis assumed convergence on C5a/C5aR1 but didn’t address whether classical, alternative, or lectin pathways drive activation in different etiologies. This mechanistic gap affects upstream therapeutic targeting and biomarker development strategies.

Source: Debate session sess_SDA-2026-04-08-gap-pubmed-20260406-062111-db808ee9 (Analysis: SDA-2026-04-08-gap-pubmed-20260406-062111-db808ee9)

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