Can pharmacological approaches achieve controlled oscillatory modulation of Nrf2-NF-κB signaling in vivo?

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Description

The debate identified this as a promising therapeutic concept but revealed no existing compounds capable of creating controlled oscillations between these pathways. This represents a critical druggability gap that could unlock temporal control of astrocyte reactivity states.

Source: Debate session sess_astrocyte-subtypes (Analysis: astrocyte-subtypes)

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