What are the structure-activity relationships for transferrin receptor binding affinity versus transcytosis efficiency in bispecific antibodies?

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Description

The debate proposed TfR-targeting bispecific antibodies but didn’t resolve the optimal binding affinity balance. Too high affinity may trap antibodies in endosomes rather than promoting transcytosis, yet this critical design parameter remains empirically undefined.

Source: Debate session sess_sda-2026-04-01-gap-008 (Analysis: sda-2026-04-01-gap-008)

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