Can astrocyte-specific PFKFB3 inhibition selectively block complement production without affecting beneficial functions?

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Description

The metabolic checkpoint hypothesis assumes glycolytic inhibition will preferentially target pathological complement production over essential astrocyte functions. However, the metabolic requirements for different astrocyte activities and their selective targetability remain unknown.

Source: Debate session sess_sda-2026-04-01-gap-009 (Analysis: sda-2026-04-01-gap-009)

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