Which specific temporal misalignments between protein aggregation and autophagy clearance are pathogenic versus adaptive?

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Description

While circadian regulation of autophagy is established, the debate did not resolve which timing mismatches actually contribute to disease progression versus those that may be protective responses. This specificity is essential for targeted chronotherapy development.

Source: Debate session sess_sda-2026-04-01-gap-011 (Analysis: sda-2026-04-01-gap-011)

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