How do circadian disruptions specifically affect SPM synthesis enzyme expression in aged microglia?

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Description

The chronotherapy hypothesis relies on circadian control of SPM synthesis, but the debate revealed uncertainty about which specific enzymes are clock-controlled and how aging affects these rhythms. This mechanistic gap limits therapeutic targeting.

Source: Debate session sess_sda-2026-04-01-gap-014 (Analysis: sda-2026-04-01-gap-014)

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