Do compensatory sphingolipid pathways generate new toxic intermediates during GCS inhibition?

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The critique highlighted that cells may upregulate alternative sphingolipid synthesis when GCS is blocked, potentially creating unforeseen toxic metabolites. This metabolic rewiring has not been characterized in neuronal contexts.

Source: Debate session sess_sda-2026-04-01-002 (Analysis: sda-2026-04-01-002)

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