Which specific chaperone systems selectively handle RNA binding protein quality control versus other cellular proteins?

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Description

The proteostasis hypothesis assumes selective enhancement is possible, but the debate didn’t establish which chaperones specifically manage RBPs like TDP-43 and FUS. This specificity is crucial for avoiding broad cellular disruption.

Source: Debate session sess_sda-2026-04-01-gap-v2-68d9c9c1 (Analysis: sda-2026-04-01-gap-v2-68d9c9c1)

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