Do microglia metabolic states directly control synaptic engulfment capacity independent of other functions?

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Description

The metabolic reprogramming hypothesis assumes pruning activity can be selectively modulated while preserving protective functions, but this functional dissociation hasn’t been demonstrated. The debate noted this as having ‘highest feasibility’ yet acknowledged ‘essential function risks’ remain uncharacterized.

Source: Debate session sess_sda-2026-04-01-gap-v2-691b42f1 (Analysis: sda-2026-04-01-gap-v2-691b42f1)

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