How do tissue-specific immune environments affect TREM2 therapeutic strategies across different organs?

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Description

The cardiac-inspired hypothesis assumes TREM2 mechanisms translate between heart and brain, but the skeptic highlighted fundamental differences in immune environments. This knowledge gap affects cross-tissue therapeutic extrapolation.

Source: Debate session sess_SDA-2026-04-06-gap-001 (Analysis: SDA-2026-04-06-gap-001)

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