Can mitochondrial DNA copy number in CSF extracellular vesicles reliably reflect neuronal mitochondrial biogenesis?

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Description

The debate proposed tracking mitochondrial biogenesis via CSF-derived extracellular vesicles but didn’t address whether these vesicles accurately represent neuronal mitochondrial status versus glial or peripheral contamination. This validation is essential for clinical utility.

Source: Debate session sess_SDA-2026-04-04-SDA-2026-04-04-gap-debate-20260403-222618-c698b06a (Analysis: SDA-2026-04-04-gap-debate-20260403-222618-c698b06a)

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