Are complement cascade activation thresholds genetically calibrated differently across SEA versus other populations in AD?

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Description

The hypothesis proposed ancestry-specific complement system responses but the skeptic noted zero direct evidence exists. This knowledge gap prevents understanding whether neuroinflammatory therapeutic targets need population-specific calibration.

Source: Debate session sess_SDA-2026-04-04-SDA-2026-04-04-gap-debate-20260403-222549-20260402 (Analysis: SDA-2026-04-04-gap-debate-20260403-222549-20260402)

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