Is the metabolic shift from ketogenesis to glycolysis in astrocytes adaptive or pathological during neurodegeneration?

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Description

The skeptic raised strong counter-evidence that lactate is neuroprotective, directly challenging the assumption that astrocyte glycolysis is harmful. This fundamental mechanistic question determines whether metabolic interventions should enhance or suppress astrocyte glucose metabolism.

Source: Debate session sess_SDA-2026-04-04-SDA-2026-04-04-gap-debate-20260403-222618-e6a431dd (Analysis: SDA-2026-04-04-gap-debate-20260403-222618-e6a431dd)

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