Can selective cGAS-STING inhibition preserve beneficial microglial functions while blocking senescence pathways?

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Description

While cGAS-STING emerged as the top-ranked target, the debate did not resolve whether therapeutic inhibition can achieve the required selectivity. The safety concerns about broad immune suppression versus the need to block senescence circuits remains unaddressed.

Source: Debate session sess_SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 (Analysis: SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402)

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