Do white matter changes precede or follow oligodendrocyte transcriptomic dysfunction in aging?

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Description

The temporal relationship between structural white matter degeneration and oligodendrocyte gene expression changes remains unclear from Allen Atlas data. Resolving causality is essential for targeting the primary pathogenic event.

Source: Debate session sess_SDA-2026-04-03-gap-aging-mouse-brain-20260402 (Analysis: SDA-2026-04-03-gap-aging-mouse-brain-20260402)

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