Description
The debate highlighted that CAG repeat expansion occurs throughout life, not just during development, but the precise timing and duration of mismatch repair suppression needed for therapeutic benefit remains unknown. This critical gap prevents clinical translation of CAG stabilization approaches.
Source: Debate session sess_SDA-2026-04-03-gap-crispr-neurodegeneration-20260402 (Analysis: SDA-2026-04-03-gap-crispr-neurodegeneration-20260402)
Evidence summary
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