Can microglia-specific AAV delivery be achieved with sufficient efficiency and specificity for therapeutic gene editing?

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Description

Multiple hypotheses relied on microglia-targeted delivery, but the debate revealed significant challenges with AAV tropism variability and off-target effects. Current vectors lack the precision needed for safe clinical application in neurodegenerative diseases.

Source: Debate session sess_SDA-2026-04-03-gap-crispr-neurodegeneration-20260402 (Analysis: SDA-2026-04-03-gap-crispr-neurodegeneration-20260402)

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