What are the genome-wide off-target mutation rates of prime editing in human neurons over extended timeframes?

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Description

While prime editing was proposed for APOE4 correction, the debate noted limited long-term safety data in neuronal cells. The accumulation of off-target edits in post-mitotic neurons could have delayed consequences not captured in current preclinical models.

Source: Debate session sess_SDA-2026-04-03-gap-crispr-neurodegeneration-20260402 (Analysis: SDA-2026-04-03-gap-crispr-neurodegeneration-20260402)

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